Effect of the mycotoxin citrinin on some hormones and on enzymes and substrates of the Embden - Meyerhof pathway in mice

Abstract M. Gupta , A. K. Dolui , S. N. Dey , S. Mukherjee , U. K. Majumder and S. K. Batabyal . Effects of the mycotoxin citrinin on some hormones and on enzymes and substrates of the Embden - Meyerhof pathway in mice. Toxicon 24, 519 – 523, 1986.—The effects of six weeks treatment with multiple i.p. doses of citrinin (15, 25 and 35 mg/kg) on some hormonal activities and on enzymes and substrates of the Embden - Meyerhof pathway in mice were studied. Adenosine triphosphatase, hexokinase, lactate dehydrogenase, lactic acid and pyruvic acid decreased in blood, liver, kidney and brain of citrinin-treated mice. Glucose levels in blood, kidney and brain increased and glycogen content of liver decreased. Cortisol, triiodothyronine and thyroxine levels of serum increased, but insulin levels decreased.