DETERMINACIÓN DE LA RELACIÓN 2-HIDROXIESTRONA/16α-HIDROXIESTRONA EN LA ORINA DE MUJERES MEXICANAS COMO INDICADOR DE RIESGO A CÁNCER DE MAMA Y SU RELACIÓN CON OTROS FACTORES DE RIESGO

The urinary ratio 2-hydroxyoestrone/16α -hydroxyoestrone (URME), has been proposed in various populations on the world as a risk indicator for breast cancer (BC), however in the Mexican population has never been determined. Objective: To determine URME Mexican women and establish its relationship with risk factors for BC. Material and Methods: Cross-sectional study of 142 premenopausal and 42 posmenopausal women. The URME was determined with the kit ESTRAMET TM and was related to risk factors for BC. Correlations and linear regressions were performed. Results: The median URME was 0.90 (RIQ 0.64-1.18). The body mass index (BMI) and early menarche contribute 5.4% of their variability (F=5.17; p<0.000). IMC participated in 6.1% of the variability of 2-hydroxyoestrone in premenopausal (F=4.40; p<0.000) and 18.1% in posmenopausal women (F=8.85; p<0.000). Conclusion: The URME was ≈50% lower than repor ted for other populations and inversely proportional to BMI.