Clindamycin lotion alone versus combination lotion of clindamycinphosphate plus tretinoin versus combination lotion of clindamycinphosphate plus salicylic acid in the topical treatment of mild tomoderate acne vulgaris: A randomized control trial
2009
Background: Acne vulgaris is a common skin disease that affects 85% to
100% of people at some time during their lives. It is characterized by
noninflammatory follicular papules or comedones and by inflammatory
papules, pustules, and nodules in its more severe forms. Aims: To
compare the efficacy of combination treatment of clindamycin+salicylic
acid, versus clindamycin+tretinoin versus clindamycin alone in the
treatment of the mild-to-moderate acne vulgaris. Methods: This was a
single-blinded, randomized clinical trial.Forty-two female patients
(age range: 15-25 years) with mild-to-moderate acne vulgaris were
selected randomly and subsequently randomized to 3 groups. Group A
patients were treated with 1% clindamycin lotion (C lotion) twice
daily. Group B patients were treated with 1% clindamycin+0.025%
tretinoin lotion once nightly (CT lotion). Group C patients were
treated with 1% clindamycin+2% salicylic acid lotion twice daily (CS
lotion) for 12 weeks. For comparison of efficacy of these treatments,
and regarding the skewed distribution of the data, Kruskal-Wallis Test
and Mann-Whitney U test were used. SPSS software was used for
statistical analysis. Results: There was a significant difference
between 3 types of treatment in the respect of the total lesion count
(TLC) improvement ( P = 0.039). The efficacy of treatment on Acne
Severity Index (ASI) was maximum for CS lotion (81.80% reduction in
ASI). CT lotion reduced ASI by as much as 73.73% during 12 weeks of
treatment. The efficacy of C lotion was calculated to be 37.87% in the
reduction of ASI. Conclusions: Our data suggested that the efficacy of
CS lotion was significantly more than C lotion with respect to the TLC
and ASI, although there was no significant difference between CS and CT
lotion.
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