Conclusion and Clinical Decision Algorithm

We have conducted a systematic qualitative review on the pharmacokinetic and pharmacodynamic drug-drug interactions associated with antiretroviral drugs currently recommended by the World Health Organization. The limitations and future directions have been provided in each Chapter Summary. Here, we will present a Clinical Decision Algorithm (modified from a previous algorithm for antimalarials) [1] to help clinicians assess the relevance of identified drug-drug interactions associated with antiretroviral agents.