Corea de huntington: Sintomas esquizofrenia-like preexistentes a los movimientos anormales y al deterioro cognitivo

espanolLa Enfermedad de Huntington (EH) es una afeccion hereditaria que produce disfuncion del nucleo estriado y sus conexiones, caracterizandose clinicamente por la triada de demencia de patron subcortical sin afasia, movimientos anormales (coreicos) y sintomas psiquiatricos no cognitivos. Estos ultimos presentan una prevalencia que oscila entre el 35-70% de los casos, siendo habitual su insuficiente exploracion por parte de los clinicos. Presentamos el caso de una paciente de 55 anos diagnosticada de EH tras estudio genetico a los 47 anos, que previamente se encontraba diagnosticada de esquizofrenia desde los 32 anos, siendo los sintomas psiquiatricos la posible forma de comienzo, precediendo en anos al inicio de los movimientos coreicos y el deterioro cognitivo. Se discuten, a la luz del caso presentado, aspectos epidemiologicos, fisiopatologicos, de diagnostico, tratamiento y sintomas psicopatologicos mas habituales que se presentan en la EH. EnglishHuntington’s Disease (HD) is an heritage neuropsychiatric disorder that involved the striatal nucleus and its conections. Its classic clinical features are movement disorders (Chorea); Subcortical Dementia without aphasia; and non-cognitive psychiatric symptoms. The prevalence of these ones is about 35-70%, and usually they are insufficiently explored by clinicians. A clinical case of a 55 years old woman is presented. The genetic diagnosis of HD was played when the patient was 47 years old. Previously, a diagnosis of schizophrenia was played at 32 years old. Psychotic symptoms were an hipothetical possible form of debut of HD, some years before of the eclossion of both movement disorders and dementia. We discuss clinical, epidemiological, physiopathological, diagnostic and therapeutics aspects of the case-report, emphasizing on different clinical psychiatric presentations usually seen in HD.