Mediator structure and rearrangements required for holoenzyme formation.

Kuang-Lei Tsai,Xiaodi Yu,Sneha Gopalan,Ti-Chun Chao,Ying Zhang,Laurence Florens,Michael P. Washburn,Kenji Murakami,Ronald C. Conaway,Joan W. Conaway,Francisco J. Asturias

Mediator structure and rearrangements required for holoenzyme formation.

2017

Kuang-Lei Tsai
Xiaodi Yu
Sneha Gopalan
Ti-Chun Chao
Ying Zhang
Laurence Florens
Michael P. Washburn
Kenji Murakami
Ronald C. Conaway
Joan W. Conaway
Francisco J. Asturias

Cryo-electron microscopy maps of the fission yeast Mediator complex and of a Mediator–RNA polymerase II holoenzyme reveal how changes in the Med14 subunit enable large-scale rearrangements of the Mediator structure that are essential for holoenzyme formation.

Keywords:

Fission
Molecular biology
Gene
Transcription (biology)
Protein subunit
Bioinformatics
Biology
RNA polymerase II
Mediator
Schizosaccharomyces pombe
Chemistry
General transcription factor
Cell biology
Yeast

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