Acute administration of the organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one induces biochemical and hematological disorders in male rats

Organochalcogens are extensively produced and employed by industry and agriculture, and the risk of occupational and environmental toxicity to them has been poorly understood. Here, we investigated the acute effect of a new organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one on biochemical and hematological parameters in male Wistar rats. The animals were treated with a single intraperitoneal injection of the organochalcogen at doses of 125, 250 or 500mgkg –1 . After 60min, the animals were sacrificed by decapitation, and the trunk blood was collected for determination of glucose, triglycerides, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase, lactate dehydrogenase, urea, creatinine, C-reactive protein, red blood cells, hematocrit, hemoglobin and white blood cells (WBC). Our results showed a reduction in cholesterol levels in all treated groups, an increase in ALT activity at doses of 250 and 500mgkg –1 , a decrease of hemoglobin and an increase in WBC in animals that received 250 and 500mgkg –1 of the organoselenium. In addition, we observed an increase in neutrophil counts at 125mgkg –1 dose and a decrease at 500mgkg –1 dose. We also verified an increase in lymphocyte counts at the dose of 500mgkg –1 . Thus, the present study shows that the acute treatment with this new organochalcogen causes biochemical changes