Acute Effects of Alcohol on Human Brain: A Resting-State fMRI Study (P04.221)

Objective: Assessing the value of ALFF and ReHo in detecting the acute effects of alcohol on healthy human brains. Background Prior studies report that amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) in the blood oxygenation level dependent (BOLD) signal are used to assess functional connectivity between different brain regions in resting-state functional magnetic resonance imaging (fMRI). Design/Methods: Eight healthy volunteers were studied with conventional MR imaging and resting-state fMRI prior to and 0.5 h, 1.5 h, 2.5 h after the initiation of acute alcohol administration. With fMRI data acquired during resting state from different time course, we used a ALFF and ReHo method to investigate spontaneous neural activity in the resting state. Breath alcohol concentrations (BrACs) were measured at each time point after drinking to estimate blood alcohol concentrations (BACs). Results: No abnormalities were found by conventional MR imaging at every time point of all subjects. The fMRI analyses showed increasing ReHo in cerebellum, left postcentral gyrus, right frontal region and increasing ALFF in left precentral gyrus, right medial frontal after acute alcohol administration. It also showed decreasing ReHo in left superior temporal gyrus, left cuneus and decreasing ALFF in cerebellum, left frontal region, and right cuneus. BrAC (BAC) were significantly increased to reach a peak at 0.5 h of both doses and decreasing gradually. Conclusions: This resting-state fMRI indicates that brain regions implicated are affected by alcohol and might provide a neural basis for alcohol9s effects on behavioral performance. Disclosure: Dr. Kong has nothing to disclose. Dr. Kong has nothing to disclose. Dr. Kong has nothing to disclose. Dr. Kong has nothing to disclose.