Current Approach in the Treatment of Preterm Premature Rupture of Membrane

Preterm premature rupture of membrane (PPROM) is common and significant cause of preterm birth and perinatal morbidity and mortality. It has been poorly defined with an obscure etiology, difficult to diagnose, and management strategies that are often diverse and controversial. Treatment options include bed rest, steroids, antibiotics, fetal and maternal surveillance, and ultimately, delivery. Determining the optimal gestational age for delivery in otherwise uncomplicated patients with PPROM involves consideration of fetal, maternal and neonatal health. In the absence of amnionitis, placental abruption, fetal distress, or advanced labor, gestational age-based conservative management of the patient with PPROM may be appropriate.