Clinicopathologic significance of expression of HMGA2 correlates with prognosis of esophageal squamous cell carcinoma after Ivor Lewis esophagectomy.

Abstract The main reason, caused the poor prognosis of esophageal squamous cell carcinoma (ESCC) after surgery, is obviously the high recurrence rate. For the patients in high risk of recurrence, it may be of value to seek indicators of recurrence, which would be useful for further treatment. High mobility group A2 (HMGA2)is a small nonhistone chromosomal protein, highly expressed in many epithelial tissue malignant tumors and closely correlated with the occurrence, development and prognosis of tumor. Its aberrant expression in various cancers was detected, at the meanwhile its expression and significance in ESCC is still remained unclear. We enrolled 127 patients with ESCC who had undergone Ivor-Lewis esophagectomy. The expression profile of HMGA2 was examined by immunohistochemistry. The result showed that the high expression of HMGA2 correlated with a higher T stage (P = 0.007),lower differentiation degree (P = 0.008),lymph node metastasis (P