Kinetics of cellular adhesion to different materials used in implants

The authors expose their observations about the kinetics of cell adesion on two materials used as implants in orthopaedic surgery, AISI, 316 L steel and passivated titanium. The kinetics of cell attachment have been compared: an initial rapid increase of bound radioactivity was observed on passivated titanium (in 5 - 30 min) and after this rapid reaction the number of attached cells increased only slowly, during the following 30 min. After incubation of 90 min, almost all cells became attached. Kinetic of BHK cell attachment on AISI 316 L differs significantly: almost all added cells were attached in 90 min but the rapid increase of attachment is observed only during the first 30 min. These observations are important for the comprension of adhesion mechanisms and characterize the properties of biocompatibility of implant materials.