Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
2016
Mutations in homology-directed repair genes like BRCA2 are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissue and a general reliance on BRCA2 in various tissues.
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