Strevertenes, antifungal pentaene macrolides produced by Streptoverticillcum LL-30F848

Abstract This report describes new polyenes isolated from fermentations with Streptoverticillium sp. LL-30F848. Structure elucidation using a variety of spectroscopic techniques, including extensive NMR studies, revealed that these pentaene macrolides lacked the otherwise common hemiketal-tetrahydropyran and aminoglycoside moieties, but still carried a carboxylic acid group. The unambiguous assignment of NMR signals attributed to the olefinic region of the pentaenes was possible for the first time, and the relative stereochemistry of the macrolide was established according to ROESY correlations. Strevertene A is the principal pentaene of the antibiotic polyene complex produced.