Derivatives of 6- (5-hydroxy-1H-pyrazol-1-yl) nicotinamide and their use as inhibitors of PHD

A compound of the formula ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein q is 0, 1 or 2; s is 0, 1 or 2; R3 whenever taken, is independently selected from the group consisting of hydrogen, hydroxyl, amino, alkylamino C1-8, cyano, halo, C1-6 alkyl optionally substituted, and C1-4alkoxy; R4 is selected from the group consisting of hydrogen, cyano, halo, methyl, ethyl, methoxy, and trifluoromethyl; R5 is selected from the group consisting ** (See formula) ** G is carbon; A is selected from the group consisting of N, O, S, CR6 and NR6; E is selected from the group consisting of N, O, S, and CR6; with the proviso that only one of A and E can be O or S; or G is N and A and E are CR6; or G and A are N and E is CR6; or G, A, and E are N; R6, each time taken is independently selected from the group consisting of hydrogen, cyano, halo, C3-8cycloalkyl, C1-6alkyl optionally substituted, C1-4alkoxy, and trifluoromethyl; R7 is selected from the group consisting of cyano and cyanomethyl; R8, each time taken is independently selected from the group consisting of hydrogen, cyano, halo, C1-4alkyl, C1-4alkoxy, and trifluoromethyl alkyl; and R9 is selected from the group consisting of hydrogen, C1-6 alkyl optionally substituted with 1 to 3 fluorine, and C3-8 cycloalkyl.