Advance on risk factors and mechanism of antitubercular drug-induced liver injury

Tuberculosis infection is still a major threat to human health due to the resistant of Mycobacterium tuberculosis, aging population, the use of hormones and the increased number of AIDS patients. Isoniazid, rifampicin, pyrazinamide and ethambutol are the first-line antitubercular agents, and will cause antitubercular agent-induced liver injury which cannot be ignored. This review briefly introduces the risk factors of antitubercular agent-induced liver injury, the mechanism of commonly used agents and gene polymorphism of metabolic enzymes. Key words: Antitubercular agents; Drug-induced liver injury; Gene polymorphism