Histamine and hepatic glutathione in the mouse

Abstract A number of histamine receptor agonists and antagonists were utilized to study the effect of histamine on hepatocellular reduced glutathione (GSH) concentrations and the potential role of histamine as a mediator of morphine-induced hepatic GSH depression. Administration of histamine, the H1-histamine receptor agonist thiazolylethylamine, the H2-histamine compound 48/80 resulted in no significant change in hepatic GSH concentrations. The H1-histamine receptor antagonist chlorpheniramine and the H2-histamine receptor antagonist ranitidine were also without significant effect on hepatic GSH and did not antagonize morphine- induced GSH depression. These observations indicate that histamine release following morphine adminstration doe not play a significant role in subsequent depletion of hepatic GSH.