Structure-Permeability Relationship of Semi-Peptidic Macrocycles - Understanding and Optimizing Passive Permeability and Efflux Ratio.

Antoine Le Roux,Emilie Blaise,Pierre-Luc Boudreault,Christian Comeau,Annie Doucet,Marilena Giarrusso,Marie-Pierre Collin,Thomas Neubauer,Florian Koelling,Andreas H. Göller,Lea Seep,Dieudonné T Tshitenge,Matthias Beat Wittwer,Maximilian Andreas Kullmann,Alexander Hillisch,Joachim Mittendorf,Eric Marsault

Structure-Permeability Relationship of Semi-Peptidic Macrocycles - Understanding and Optimizing Passive Permeability and Efflux Ratio.

2020

Antoine Le Roux
Emilie Blaise
Pierre-Luc Boudreault
Christian Comeau
Annie Doucet
Marilena Giarrusso
Marie-Pierre Collin
Thomas Neubauer
Florian Koelling
Andreas H. Göller
Lea Seep
Dieudonné T Tshitenge
Matthias Beat Wittwer
Maximilian Andreas Kullmann
Alexander Hillisch
Joachim Mittendorf
Eric Marsault

We herein report the first thorough analysis of the structure-permeability relationship of semi-peptidic macrocycles. In total, 47 macrocycles were synthesized using a hybrid solid phase/solution s...

Keywords:

Permeability (electromagnetism)
Chemistry
Organic chemistry
Efflux
Chemical engineering
passive permeability

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