Local relapse after radiotherapy in locally advanced breast cancer patients

The study includes 99 patients with a locally advanced breast cancer. The mean age was 60.9±12.3 years, and 38.4% of the patients had a T3 tumors and the remaining patients T4 lesions. The most common histology was infiltrating ductal carcinoma, and in the 98% of the histologic samples the grade was moderate or high. All patients were treated with modified radical mastectomy, and radiotherapy. 37.4% of the patients received neoadjuvant chemotherapy. The radiotherapy schedule was 50.2%±1.6 Gy (1.8–2 Gy/day) with 1.25 MeV photons. Median follow-up is 4 years. The 5-year local-regional control probability, disease free survival and the distant disease free survival are 96.5%±3.9%, 61.4%±12.3% and 62.1%±12.3% respectively. The 4-year overall survival for patients with T3 tumors was better than for T4 lesions (85.8%±11.5% vs 68.5±13.1%) (p=0.18). In conclusion, the management of locally advanced breast cancer, should include surgery, radiotherapy and chemotherapy. The local control was excellent, and although patients die because distant disease they improve ed showed an survival.