Vascular lesion of hereditary hemorrhagic telangiectasia.

THE present report of a classic case of hereditary hemorrhagic telangiectasia (Rendu–Osler–Weber disease) is presented because it supplies histologic data relevant to the basic vascular defect. The autopsy findings emphasize the diversity of tissues that display the vascular involvement, and may explain the severe cardiopulmonary symptoms suffered by the patient. Case Report J.R.J., a 68-year-old man, was hospitalized for the 9th time after an acute illness of 2 weeks' duration. The referring diagnosis was a ruptured abdominal viscus. The genetic background has been reported elsewhere.1 Since that report he is the 2nd member of generation II who has died. His . . .