Halogenated Hydrocarbons and Drug Metabolism: The Effect of Fluorocarbons on Hexobarbital Sleeping and Zoxazolamine Paralysis Times in Mice

Abstract : A screening program has been initiated for the purpose of exploring the possibility that the inhalation exposure of rodents to selected halogenated hydrocarbons may affect enzymes of the hepatic smooth endoplasmic reticulum, the so-called microsomal drug-metabolizing enzymes. The materials of interest to the Air Force which have come under investigation include bromotrifluoromethane, trichlorotrifluoroethane, and dibromotetrafluoroethane. Some work with halothane has also been done for comparative purposes.