Mechanisms of disturbance in regenerative processes in chronic traumatic osteomyelitis

: Analysis of long-term observation and treatment of patients with long bone fractions complicated by chronic traumatic osteomyelitis and relevant literature data made it possible to elucidate general and local mechanisms of disturbance of regenerative processes. Key pathogenetic factors in chronic traumatic osteomyelitis proved to be stress reaction, impaired functional thyroid activity, suppressed immune responsiveness, disturbed bone metabolism, dysbalance of micro- and macroelements, secondary disturbances of peripheral blood flow in the affected limb segment (chronic venous insufficiency), formation of Staphylococcus-dominated microflora in wound discharge, enhanced pathological bone resorption followed by regional osteoporotic changes. It is concluded that the development of pathogenetically-sound treatment modalities based on the above findings will help to avoid undesirable outcomes of chronic traumatic osteomyelitis.