Metabolik sendromda ürik asit düzeyi ile nonalkolik yağlı karaciğer hastalığı arasındaki ilişki

Ozet Amac. Bu calismanin amaci metabolik sendrom (MS) hastalarinda non-alkolik yagli karaciger hastaliginin (NAYKH) sikligini ve serum urik asit degeri ile arasindaki iliskiyi arastirmaktir. Yontem. Calismaya 26’si erkek ve 34’u kadin toplam 60 MS olgusu ile 21’i erkek ve 21’i kadin toplam 42 saglikli birey alindi. On iki saatlik aclik sonrasi alinan kan orneklerinde; aclik kan sekeri (AKŞ), trigliserid, yuksek dansiteli lipoprotein, dusuk dansiteli lipoprotein (LDL), urik asit duzeyleri ve insulin degerlerine bakildi. Insulin direncini belirlemek icin HOMA-IR formulu kullanildi. Karaciger yaglanmasinin derecesi ultrasonografik olarak degerlendirildi. Bulgular. Calismamizda MS grubundaki urik asit duzeyleri, kontrol grubu olgularinin urik asit duzeylerinden istatistiksel olarak anlamli olacak sekilde yuksekti (p<0,05) ve MS komponentleri arttikca urik asit seviyelerinin de yukseldigi gozlendi. MS olgularimizda %78,3 oraninda karaciger yaglanmasinin oldugu; urik asit degerlerinin bu hastalarda anlamli derecede yuksek oldugu, bu artisin yaglanmanin derecesi ile dogru orantili oldugu saptandi. Sonuc. MS ile serum urik asit degeri ve NAYKH arasinda yakin bir iliski mevcuttur. Calismamizda ozellikle serum urik asit seviyesinin artisi karacigerdeki yaglanmanin derecesi ile dogrudan baglantili bulunmustur. Bundan yola cikarak, serum urik asit seviyesi artisinin, NAYKH’nin patogenezinde rol oynayabilecegini dusunmekteyiz. Anahtar sozcukler: Metabolik sendrom, karaciger yaglanmasi, urik asit Abstract Aim. The purpose of this study is to investigate the frequency of non-alcoholic fatty liver disease (NAFLD) in patients diagnosed as metabolic syndrome (MS) and also to find out its relation with serum uric acid levels. Methods. A total of 60 MS patients (26 male, 34 female) and 42 healthy individuals (21 male, 21 female) were included in the study. After a fasting period of 12 hours, serum glucose, triglyceride, high density lipoprotein, low density lipoprotein, uric acid and insulin levels were determined. HOMA-IR formula was used to determine insulin resistance. Ultrasonography was used in showing the grade of hepatosteatosis. Results. Mean serum uric acid level of the MS group was significantly higher than the control group in our study (p<0.05) and we observed that serum uric acid levels increase as the number of MS components increase. We found the frequency of hepatosteatosis in our metabolic syndrome patients to be 78.3%. Serum uric acid levels were significantly elevated in these patients and this elevation showed a positive correlation with the grade of hepatosteatosis. Conclusion. There is a close relationship between MS and serum uric acid levels and also with NAFLD. Especially the increase in serum uric acid levels were found to be directly related with the degree of hepatosteatosis. Relying on this fact; we think that the increased uric acid levels in MS patients could have played a role in the NAFLD pathogenesis. Keywords: Metabolic syndrome, hepatosteatosis, uric acid