PPD-Induced Immunoglobulin Production in Human Peripheral Blood Lymphocytes: II. Separation of PPD-Reactive Helper T Cells from PWM-Reactive Helper T Cells in Polyclonal Immunoglobulin Production of Human Peripheral Blood Lymphocytes
1979
We investigated the relationship between PPD-reactive helper T cells and PWM-reactive helper T cells in polyclonal Ig production of human PBL. Elimination of PPD-reactive T cells by BUdR + light treatment resulted in a loss of helper function in PPD-induced Ig production, but had no effect on helper function in PWM-induced Ig production. On the other hand, elimination of PWM-reactive T cells resulted in a loss of helper function in both PPD-induced Ig production and PWM-induced Ig production.
A blast cell-enriched fraction that was generated by PPD and separated by the velocity sedimentation method contained helper function in both responses. On the other hand, blast cell-depleted fractions did not contain PPD-reactive helper function, although the PWM-reactive helper function was evident.
These results strongly suggest that PPD-reactive helper T cells are included in PWM-reactive helper T cells.
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