Research progress on the relationship of mitochondrial dysfunction to diabetic vascular complications

Diabetes is an endocrine disease characterized by long-term hyperglycemia with or without progressive vascular disease, involving systemic complications, mainly reflected in macroangiopathy and microangiopathy, which are the leading cause of death and disability of diabetes. However, its pathogenesis has not yet been fully clarified. Endothelial cells are an important part of maintaining vascular homeostasis, and endothelial dysfunction is the initiator or promoter of diabetic vascular complications. Mitochondrial dysfunction also plays an important role in the pathological process of vascular endothelial cell dysfunction. In recent years, researches of the mechanism of mitochondria-vascular endothelial function and the drug development have become a hot topic in prevention and treatment of diabetes. The present paper mainly expounds the relationship of mitochondrial dysfunction to vascular complications of diabetes, aiming to provide the basis for drug development and clinical diagnosis and treatment. DOI: 10.11855/j.issn.0577-7402.2020.03.17