Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans

Abigail W. Bigham,Romel D. Mackelprang,Connie Celum,Guy de Bruyn,Kristin Beima-Sofie,Grace John-Stewart,Allan R. Ronald,Nelly Mugo,Kati J. Buckingham,Michael J. Bamshad,James I. Mullins,Mj McElrath,Jairam R. Lingappa

Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans

2014

Abigail W. Bigham
Romel D. Mackelprang
Connie Celum
Guy de Bruyn
Kristin Beima-Sofie
Grace John-Stewart
Allan R. Ronald
Nelly Mugo
Kati J. Buckingham
Michael J. Bamshad
James I. Mullins
Mj McElrath
Jairam R. Lingappa

Objective: We evaluated genetic variants in 51 candidate genes encoding proteins that interact with HIV-1 during the virus life cycle for association with HIV-1 outcomes in an African cohort.

Keywords:

Viral replication
Virology
Haplotype
Viral life cycle
Candidate gene
Gene
Cell Cycle Gene
Genome-wide association study
Viral load
Genetics
Biology
SNP
Population stratification
Case-control study
Single-nucleotide polymorphism
Odds ratio

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