Assessment of biocompatibility of cranberry and grape seed extract as an intracanal medicament

The present study was conducted to evaluate and compare the biocompatibility of cranberry and grape seed extract as intracanal medicaments (ICM). Gel form of intracanal medicaments were formulated using cranberry and grape seed extract to which carbopol was added as a biocompatible polymer. Formulated intracanal medicaments were evaluated for biocompatibility and compared with commercially available Chlorhexidine gel intracanal medicament. Intracanal medicaments were divided into four study groups i.e., Group I containing cranberry ICM, GroupII containing grape seed ICM, Group III containing chlorhexidene gel, and Group IV containing saline as control, for the evaluation of biocompatibility property using MTT (3-(4) 5-Dimethyl-thiazol-Zyl) - 2,5 biphenyl tetrazolium bromide) assay. The present study suggests that ICM containing Grape seed extract (67.08%) showed least cell inhibition followed by cranberry extract ICM(73.37%) and chlorhexidene gel ICM (78.71%) at maximum concentration of 320mg/ml. ICM containing Grape seed extract and cranberry extract showed good biocompatibility and can be used as alternate to commercially available chlorhexidine gel ICM.