4-oxoquinoline derivative and anti-hiv drug combination dosage comprising

SUMMARY The present invention, (S)-6-(3- chloro-2-fluorobenzyl) -1- (1-hydroxymethyl-2-methylpropyl) -7-methoxy-4-oxo-1,4-dihydroquinoline including 3-carboxylic acid ( "compound a") or a pharmaceutically acceptable solvate or salt thereof in combination with at least one other anti-HIV agent, inhibits or integrase for treating HIV infection on combination therapy for. In some aspects of the present invention, other anti-HIV agent is selected from reverse transcriptase inhibitors and protease inhibitors. In certain embodiments of the present invention, other anti-HIV agents, AZT, 3TC, PMPA, efavirenz, indinavir, nelfinavir, are selected from the combination of the combination and PMPA / 3TC of AZT / 3TC. Compound A is for with integrase-specific high inhibitory activity, when used in combination with other anti-HIV agents, can provide a little no side effects in combination therapy in humans. .BACKGROUND