Development of a Clinical Lab Assay for Assessment of Eosinophil Peroxidase in Sputum

M O N D A Y 568 Poor Sleep Quality As a Risk Factor for Poorly-Controlled Asthma in Children Youn Ho Shin, MD, Sun Jung Jang, Ji Hyeon Baek, Hye Mi Jee, MD, Kyu Young Chae, Kyu-Earn Kim, MD, PhD, Man-Yong Han, MD, PhD; Mayo Clinic, Rochester, MN, Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Seoul, South Korea, Department of Pediatrics, CHA University School of Medicine, Seongnam, South Korea, Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea, South Korea, Yonsei University College of Medicine, Seoul, Korea. RATIONALE: Sleep respiratory breathing disorder (SRBD) is a risk factor for uncontrolled asthma in adults; however, it is unclear as to whether it is also a risk factor for uncontrolled asthma in children. We investigated the relationship between SRBD and clinical variables, the lung function, and the Childhood-Asthma Control Test (C-ACT) in children with asthma according to level of asthma control. METHODS: This is a cross-sectional study on 220 asthmatic children. SRBD was assessed by using the Pediatric Sleep Questionnaire (PSQ). Asthmatic children were classified into one of 3 groups according the GINA guideline: well-controlled asthma, partly-controlled asthma, and uncontrolled asthma. Logistic regression analysis was used to calculate the associations of SRBD with partly controlled asthma or uncontrolled asthma. RESULTS: Of 220 children with asthma, 19.6% of the children experienced SRBD. There were significant differences in lung function measures and the C-ACT score (All P < 0.05), but not in the PSQ score (P 5 0.176) among the children of different level of asthma control. The PSQ score was correlated to FEV1/FVC values (r5 -0.159, P5 0.018), but not FEV1 % predicted (r5 0.007, P5 0.922). By logistic regression analysis, a high PSQ score increased the odds of having partly-controlled/uncontrolled asthma by 8.56 (95% CI 1.36-53.74, P 50.022) after adjustment for compounding factors. CONCLUSIONS: We found that SRBD was an independent risk factor for partly controlled or uncontrolled asthma in children. Further research is warranted to determine whether improving sleep quality may also enhance level of asthma in children.