Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor

Sandra Gouveia-Figueira,Jessica Karlsson,Alessandro Deplano,Sanaz Hashemian,Mona Svensson,Marcus Fredriksson Sundbom,Cenzo Congiu,Valentina Onnis,Christopher J. Fowler

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor

2015

Sandra Gouveia-Figueira
Jessica Karlsson
Alessandro Deplano
Sanaz Hashemian
Mona Svensson
Marcus Fredriksson Sundbom
Cenzo Congiu
Valentina Onnis
Christopher J. Fowler

Background Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One su ...

Keywords:

Stereochemistry
Prostaglandin
Endocannabinoid system
Propanamide
Hydrolysis
Substrate (chemistry)
Cyclooxygenase
Arachidonic acid
Fatty acid amide hydrolase
Chemistry
Biochemistry

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