Effect of Bone Mineral with or without Collagen Membrane in Ridge Dehiscence Defects Following Premolar Extraction

Background: The purpose of this investigation was to evaluate the regenerative response to deproteinized porous bovine bone mineral (BM) when used alone or in combination with a bioresorbable porcine-derived bilayer collagen membrane (CM) for alveolar ridge augmentation in dogs. Materials and Methods: The mandibular premolars were extracted unilaterally and three ridge defects were induced in six mongrel dogs. Each defect site was randomly assigned to one of the following treatment groups: BM alone (group A), BM in combination with CM (group B), or neither membrane nor bone graft, which served as a control (group C). No adverse events occurred during the experimental period. Dental computed tomography (CT) scans were taken after postoperative periods of 8 and 16 weeks. Results: The percentage of CT-derived bone density in groups A and B was significantly different from that of group C (p<0.01) at 8 and 16 weeks. The percentage of CT- derived bone density of the dogs in Group B was significantly higher than that of those in group A at 8 and 16 weeks (p<0.01). Gross evaluation of the 3-dimensional CT reconstruction image of the canine mandibles after 16 weeks of implantation showed that group B had the greatest amount of bone augmentation and excellent thickness of the buccal aspect of the alveolar ridge. Conclusion: These results suggest that BM leads to more successful bone regeneration