Design and self-assembly of two-dimensional DNA crystals
1998
Molecular self-assembly presents a `bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA
molecular structures and intermolecular interactions are particularly
amenable to the design and synthesis of complex molecular objects. We
report the design and observation of two-dimensional crystalline forms
of DNA that self-assemble from synthetic DNA double-crossover
molecules. Intermolecular interactions between the structural units are
programmed by the design of `sticky ends' that associate according to
Watson-Crick complementarity, enabling us to create specific periodic
patterns on the nanometre scale. The patterned crystals have been
visualized by atomic force microscopy.
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