Inhibition of Cysteamine-Induced Duodenal Ulcers in OCT1/2 Knockout Mice

COX-2 and CGRP, downregulation of SOD but no effect on proinflammatory cytokines was observed. In rats with deactivated sensory nerves, the protective effect of orexin on the gastric mucosa against ethanol induced lesions was attenuated. This was associated with decreased expression of HSP70 and increase of COX-2 and SOD. No changes in proinflammatory cytokines were observed. In addition, orexin treatment caused a significant upregulation of CGRP expression. Conclusion: Orexin-A protects the gastric mucosa from acute lesions induced by 75% ethanol and this protective effect is mediated at least in part by sensory nerves and CGRP and stimulatory effect of this peptide on expression of HSP70 and the anti-oxidant enzyme SOD.