Acute Isoniazid Poisoning Presenting With Convulsions And Coma

Purpose : We report a case of acute isoniazid intoxication presented with convulsions, and coma. Case : An 8-year-old boy had taken 10 isoniazid tablets (100mg/tb) which had been started as a prophylactic. A nasogastric catheter was administered and gastric lavage was performed followed by the administration of activated charcoal. Immediately after the procedure, sudden convulsions began, which subsided within five minutes of the administration of diazepam infusion. As an antidote, Pyridoxine 1.5 gr ( 50 mg/kg/day),was administered intravenously. After 8 hours the patient regained consciousness, his general condition normalized and oral nutrition was started. Conclusions : Pyridoxine administration is the best way of treating convulsions. Parenteral pyridoxine administration is an effective method in isoniazid intoxication.