Hypervalent Iodine(III)-Induced Intramolecular Cyclization Reaction of Substituted Phenol Ethers with an Alkyl Azido Side-Chain: A Novel and Efficient Synthesis of Quinone Imine Derivatives.

Novel and efficient syntheses of quinone imine ketals (2a-j) and quinone imines (4a-h) from substituted phenol ethers (1a-k) bearing an alkyl azido side-chain using the combination of hypervalent iodine(III) reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA) and trimethylsilyl trifuoromethanesulfonate (TMSOTf), have been developed.