Pensamientos Negativos y Estrés asociados al Receptor de Serotonina 5HT1a en Mujeres con Fibromialgia

Fibromyalgia (FM) is a chronic non-degenerative disease characterized by generalized pain throughout the body, fatigue, and cognitive disturbances. 5HT1a is a receptor associated with anxiety, fear and stress. Few studies link 5HT1a receptor gene expression with negative thoughts and stress in FM. Therefore, the objective was to evaluate the correlation between the 5HT1a receptor with stress and negative thoughts, in women with FM. The study included 49 women with FM, from the “Eduardo Liceaga” General Hospital of Mexico of the Rheumatology service. Stress and negative thoughts were evaluated from the application of psychological instruments: Negative Automatic Thoughts Questionnaire (ATQ-30) and Perceived Stress Scale (PSS). The gene expression of 5HT1a was evaluated by real-time PCR from RNA extraction, using blood. The psychological evaluation and blood extraction was carried out at two different times. High levels of stress and negative thoughts were identified specifically self-reproach, both factors showed a negative correlation with 5HT1a, in which the perception of stress is a predictive model of the expression of 5HT1a. It can be concluded that the high perception of stress and having thoughts of self-reproach possibly produce changes in the reduction of the gene expression of the 5HT1a receptor in fibromyalgia, these results support the idea that stress management and the modification of negative thoughts are potential factors for a psychological treatment in this population due to the impact it could have on a biological level.