Synthesis and study biological activity of new heterocyclic compounds based on sugar

Gluco-triazole derivatives were prepared CuCl catalyzed click reactions between 4,4'-diazido-3,3'-dimethyl-1,1'- biphenyl and Synthesis of 2-Propynyl (2,3,4,6-tetra-O-acetyl-α-D-gluco pyranoside). Whereas gluco-tetrazole compound prepared employing NH4Cl catalyzed cycloaddition reaction between acetylated glucosyl azide and 3,3'-dimethyl-[1,1'- biphenyl]-4,4'-dicarbonitrile. Finally elimination of the protection groups via methanol with Potassium carbonate afforded end products. All prepared heterocyclic derivatives were evaluated toward inhibition of bacterial growth (Escherichia coli, Staphylococcus aureus). Slight growth inhibition compared to standard drug is Azithromycin was showed at a highest concentration of 25 µg/mL, while no growth inhibition was showed at the lowest concentration (10 µg/mL).