Cytokine patterns in fibromyalgia and their correlation with clinical manifestations.

Objective To examine the possible role of the soluble factor in fibromyalgia (FM) by studying the correlation of cytokine levels with the patientsʼ clinical and psychiatric profile. Methods Eighty FM patients underwent clinical and psychiatric evaluations, and plasma levels of cytokines (IL-1, IL-6, IL-8, IL-10, TNF-α), aspecific markers of inflammation, rheumatoid factor (RF), anti-extractable nuclear antigen (ENA) antibodies, and anti-nuclear factor (FAN) were measured. Results Higher levels of IL-10, IL-8 and TNF-α were found in FM patients than in controls. Significant correlations between the biochemical parameters and clinical data were found. Conclusion The higher levels of cytokines found in FM patients suggest the presence of an inflammatory response system (IRS) and highlight a parallel between the clinical symptoms and biochemical data. They support the hypothesis that cytokines may play a role in the clinical features of fibromyalgia. In addition, the similar cytokine patterns found in FM patients with different psychiatric profiles suggests that IRS impairment may play a specific role in the disease.