A comparison of dexmedetomidine versus midazolam for sedation, hemodynamic and intraocular pressure response during cataract surgery under conscious sedation: A randomized, double-blind trial

Objectives To investigate the efficacy and safety of sedation and hemodynamic changes with dexmedetomidine and midazolam in cataract surgery. Methods Patients with ASA physical status I–II undergoing elective cataract surgery were randomly allocated in two groups to receive dexmedetomidine or midazolam for conscious sedation. Intraocular pressure (IOP), continuous peripheral oxygen saturation (SpO2), heart rate, mean arterial pressure (MAP), Ramsay Sedation Scale (RSS), during and after the procedure. Results Patients in the dexmedetomidine group (n = 30) had lower heart rate, MAP, higher SpO2 and lower RSS scores during sedation than those in the midazolam group .There was decreased in  intraoccular pressure  after sedation  and statistically was not significant. However satisfaction was higher in the dexmedetomidine group than the midazolam group. There were no any kind of complication reported in either group. Conclusion Dexmedetomidine is a good safety profile as compared to midazolam group and an effective sedative agent for use in cataract surgery. Keywords: Cataract surgery, Dexmedetomidine, Hemodynamics changes, Intraocular pressure, Midazolam