Trends in comorbidities among HIV-infected hospital admissions in New York City from 2006-2016.

BACKGROUND Due to the advent and success of antiretroviral therapy (ART), the number of people living and aging with HIV has grown substantially. Although PLHIV are experiencing longer life expectancies, this achievement may be undermined by increasing and disproportionate chronic disease burden among PLHIV. METHODS This study is a retrospective analysis of adult (≥18 years) inpatient hospital discharges from a large hospital system in the New York City, New York metropolitan area, between January 1st, 2006 and December 31st, 2016. We aimed to investigate 1) changes in the prevalence of Charlson-defined comorbidities among PLHIV hospitalized between 2006 and 2016, and 2) changes in the unadjusted prevalence ratio (PR) of comorbidities in HIV-positive versus HIV-negative admissions over time. RESULTS Of 898,139 hospital admissions from 2006-2016, 19,039 (2.1%) were HIV-positive. Across all admissions during the study period, the greatest comorbidity disparities between HIV-positive and HIV-negative admissions were mild liver disease (PR=4.9, 95% CI: [4.8,5.1]), moderate or severe liver disease (PR=2.2 [2.0,2.4]), and chronic pulmonary disease (PR=1.8 [1.8,1.8]). CONCLUSIONS The prevalence and relative burden of comorbidities among hospitalized PLHIV is changing over time. Careful monitoring and intensive discharge planning may be effective strategies for addressing the evolving health needs of PLHIV.