High expression of long noncoding RNA Sox2ot is associated with the aggressive progression and poor outcome of gastric cancer.

Abstract The aim of our study was to investigate the expression of long non-coding RNA Sox2ot (Sox2ot) in gastric cancer (GC) patients and its association with clinicopathologic parameters and the prognosis. Quantitative real-time polymerase chain reaction was performed to detect Sox2ot expression in 155 GC tissues and paired adjacent normal tissues. The relationships between Sox2ot expression and the clinicopathological features of GC patients were analyzed. Furthermore, overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using the Cox proportional hazard analysis. Sox2ot expression levels were decreased in cancerous tissues compared to their corresponding non-cancerous controls (p