Abstract 12407: Plasma B-type Natriuretic Peptide Level is Useful to Predict Incidence for Both Types of Heart Failure With and Without Left Ventricular Systolic Dysfunction in the General Population

Aim: It remains unknown whether the predictive abilities of plasma B-type (BNP) are viable for either heart failure (HF) with preserved ejection fraction (HFpEF) or with reduced ejection fraction (HFrEF) in the general middle-aged and elderly population. Methods: Participants were recruited from the general population (n = 14,141; mean age=63 years). A Cox regression analysis adjusting for traditional risk factors (age, sex, BMI, hypertension, diabetes, atrial fibrillation, eGFR, smoking) was performed to examine the hazard ratio (HR) of plasma BNP for each type of HF. Moreover, receiver-operating-characteristics (ROC) analysis were used to determine the predictive abilities of plasma BNP for the incidence of two types of HF. Results: During a median follow-up of 9.0 years, new onset of HF (defined by Framingham criteria) was found in 142 participants (HFpEF, n = 74; HFrEF, n = 68) in the cohort. The HRs for both HF in terms of per one standard deviation (1 SD) increment (as a continuous variable) and val...