SYNTHESIS AND ANTI-INFLAMMATORY EVALUATION OF NEW 5- ARYLIDENE-3- METHYLSULPHONYL THIAZOLIDINE-2, 4-DIONES.

A series of novel thiazolidine-2, 4-dione derivatives containing 3methyl sulphonyl moiety were synthesized by following convenient synthetic protocols to investigate their potential anti-inflammatory activity. The chemical structures of the synthesized compounds were elucidated by spectral and elemental analyses. The evaluated compounds in the series exhibited significant anti-inflammatory activities when compared with reference drug indomethacin.