Ameliorative Effect of Plant Extract of Suruhan (Peperomia pellucida) on Renal Histological Abnormality in Alloxan-Induced Hyperglycemic Mice

Diabetes mellitus, caharacterized by hyperglycemia, is a major risk factor of kidney disease. The study aimed to determine whether suruhan plant (Peperomia pellucid) claimed to have anti-diabetic properties, can improve renal histological abnormalities in alloxan-induced hyperglycemic mice. Male albino mice (n=25) were grouped into five (5 mice each). Group 1 treated with alloxan at the dose of 150 mg/kg BW (as negative control). Group 2 was given alloxan and glibenclamide of 0.65 mg/kg bw (as positive control). Group 3, 4 and 5 were treated with alloxan and plant extracts at the dose of 56, 112 and 168 mg/kg BW respectively. Injection of alloxan was done 3 times in 6 days and the plant extract was given every day for 35 days. Results showed that plant extract of suruhan significantly reduced histological abnormalities of renal tubular and glomerular cells. In conclusion plant extract of suruhan is potent to be used as anti hyperglycemic agent and diabetes-related complication.