The relationship between pulse pressure, insulin resistance, and beta cell function in non-diabetic Korean adults

Abstract Aims The present study was conducted to assess the association of pulse pressure (PP) with insulin resistance and beta cell function in Korean non-diabetic populations. Methods This study used the data from the 2015 Korean National Health and Nutrition Examination Survey including 4380 adults, aged 20 or older. Results A multivariate analysis revealed that systolic blood pressure (SBP) ( β  = 0.089, 95% confidence interval [CI], 0.004–0.011; p  β  = −0.057, 95% CI −0.014 to −0.003; p = 0.002), and PP ( β  = 0.069, 95% CI 0.004–0.011; p  β  = −0.068, 95% CI −0.676 to −0.203; p  B ). In the analysis of covariance test, after adjusting for related variables (except age), the quartiles of PP were not associated with HOMA-IR (p = 0.191) and were inversely associated with HOMA- B (p  B (p = 0.027). Conclusion PP was positively associated with insulin resistance and beta cell function in non-diabetic Korean adults.