Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors

Objective: Reactive oxygen species (ROS) and antioxidant capacity have been implicated in the pathogenesis of various diseases, and cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. Materials and Methods: In this study, we aimed to identify serum Nitric Oxide (NO), Arylesterase (ARE) and paraoxonase (PON) activities in patients with renal tumors. Serum ARE, PON and NO levels were measured by spectrophotometer. Results: Increased activity of serum nitric oxide (NO) was determined in cancer group. Serum Arylesterase (ARE) were significantly lower in the patient group than the control group. Increased activity of Serum paraoxonase (PON) were detected in the control group (p < 0.05). Conclusion: Our results indicates that Nitric oxide (NO), arylesterase (ARE) and paraoxonase (PON) activities may play an important role in the pathogenesis of renal cell cancer.