Human herpesvirus-6 (HHV-6, HBLV) in sarcoidosis and lymphoproliferative disorders

Abstract Serologie studies were done to estimate the antibody prevalence against human herpesvirus 6 (HHV-6) in patients with malignant lymphomas, Sjogren's syndrome and sarcoidosis. Serologie studies showed IgG antibody titers against HHV-6 in up to 41% of patients with sarcoidosis, 50–70% with malignant lymphomas and in 36% with Sjogren's syndrome. In situ hybridization on lymph node biopsies was positive for HHV-6 genome in 1 out of 5 sarcoidosis lymph nodes.