New concept of light dosimetry in photodynamic therapy: the control by using an ARX modeling

The control of light dosimetry during photodynamic therapy requires the knowledge of all the optical coefficient in situ. Therefore, a sensor based upon the backscattering phenomenon has been conceived. It is described in the first part. The second part of the paper shows how the combination of the Kubelka and Munk's theory and an ARX modeling of light gives access to the required values. In the last part the results obtained in vitro on optical phantoms and in vivo on nude mice are analyzed.© (1995) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.