Trabeculectomy and Mitomycin C (Trab-MMC) for uveitic glaucoma: post surgical interventions

Purpose: To examine the outcome of patients at who underwent trabeculectomy and MMC for refractory uveitic glaucoma and determine the post operative interventions required Methods: The Birmingham ReGAE (Research into Glaucoma and Ethinicity) Project is an open, prospective, consecutive series of patients who had undergone trabeculectomy with MMC. The surgery was performed by a single surgical team at the Birmingham and Midland Eye Centre Results: Twenty eyes of 25 patients with uveitic glaucoma underwent Trab-MMC for uncontrolled IOP despite maximally tolerated medical treatment. Mean follow-up was 650 days. Mean pre-op IOP was 26.7 mmHg and post-op was 11.5 mmHg. 92 % of trabeculectomies reached complete success (IOP ≤ 21 mmHg without medication). Subconjunctival injections of 5-fluorouracil were performed on 10 eyes (36 %). Bleb needling revision was performed on 5 eyes (18 %).Visual loss > 2 lines occurred in 1 case (3.8%) due to delayed hypotony maculopathy Conclusions: Trabeculectomy and Mitomycin C is effective in this complex series of patients but do require considerable post surgery manipulation