Synthesis of 5‐Substituted Pyrimidines. ortho‐Directed Lithiation of Pyrimidine Derivatives.
1991
ortho-Directed lithiation of some pyrimidines has been investigated. Treatment of 2- and/or 4-alkoxy or acylaminopyrimidine with lithium 2,2,6,6-tetramethylpiperidide in ether at 0°, followed by quenching with various electrophiles afforded the corresponding 5-substituted pyrimidines.
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