Effect of lysozyme chloride on abnormal sensation in the throat.

If the main cause of abnormal sensation in the throat were due to inflammation of the region, a majority of the patients with the sensation should be treated successfully with anti-inflammatory drugs.In order to test the hypothesis the authors administered lysozyme chloride (Neuzym(R)), an anti-inflammatory agent, orally for 2 weeks in adosage of 270-300mg/day to 92 patients(35males and 57 females)with abnormal sensation in the throat. It was considered to be effective when the abnormal sensation improved subjectively by 50% or more. The medication was effective in 41% of the patients within one week, in 52% in two weeks and 55% in three weeks(one week after the termination of the treatment). These efficacy rates were not as high as had been expected.Thus, the present study did not prove that abnormal sensation in the throat is a symptom closely related to inflammatory changes.